Monday, 2 November 2015

From Protecting the Heart to Improving Athletic Performance - the Benefits of Local and Remote Ischaemic Preconditioning


This review was also finally published. This is the second output of the last collaboration we setup with the Olympic Medical Institute before its closure. With colleagues from the Hatter Institute in UCL we started questioning the protocols employed in the clinical setting and in the sport setting for remote ischaemic preconditioning. Our first paper was a pilot study to look at the dose-response of common methods, this one is a comprehensive review on this topic with the hope that more and better studies are designed to define safe and effective protocols.
The abstract is below, you can access the article online here.

 2015 Oct 19. [Epub ahead of print]

From Protecting the Heart to Improving Athletic Performance - the Benefits of Local and Remote Ischaemic Preconditioning.

Abstract

Remote Ischemic Preconditioning (RIPC) is a non-invasive cardioprotective intervention that involves brief cycles of limb ischemia and reperfusion. This is typically delivered by inflating and deflating a blood pressure cuff on one or more limb(s) for several cycles, each inflation-deflation being 3-5 min in duration. RIPC has shown potential for protecting the heart and other organs from injury due to lethal ischemia and reperfusion injury, in a variety of clinical settings. The mechanisms underlying RIPC are under intense investigation but are just beginning to be deciphered. Emerging evidence suggests that RIPC has the potential to improve exercise performance, via both local and remote mechanisms. This review discusses the clinical studies that have investigated the role of RIPC in cardioprotection as well as those studying its applicability in improving athletic performance, while examining the potential mechanisms involved.

KEYWORDS: 

Acute kidney injury; CABG; Cardioprotection; Exercise performance; Ischemia-reperfusion injury; PCI; Perconditioning; Postconditioning; Remote ischemic preconditioning; Sports
PMID:
 
26477661
 
[PubMed - as supplied by publisher]




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