Wednesday, 12 September 2012

New article published #3: whole body vibration effects on obese subjects

This article was published on Obesity Facts. It is the result of a collaboration i have with the Italian Auxological Institute. An organisation working every day to help obese patients and trying to develop innovative approaches to weight management. In this experiment we showed how whole body vibration with and without additional loading can induce acute increases in Growth Hormone which is very difficult to obtain with other forms of exercise in this population. In the obese, some endocrinological disturbances during acute endurance and resistance exercise have been identified inmany studies: a blunted growth hormone response, atrial natriuretic peptide and epinephrine release, and greater cortisol and insulin release. These hormonal disturbances might contribute to a suppressed lipolytic response, and/or suppressed skeletal muscle protein synthesis, as a result of acute endurance or resistance exercise, respectively. Our finding suggests that this form of exercise has the potential to be effective at least in the initial stages of an exercise programme in this population.

Obes Facts. 2012 Aug 24;5(4):567-574. [Epub ahead of print]

Growth Hormone-Releasing Effects of Whole Body Vibration Alone or Combined with Squatting plus External Load in Severely Obese Female Subjects.

Giunta M, Cardinale M, Agosti F, Patrizi A, Compri E, Rigamonti AE, Sartorio A.

Source

Istituto Auxologico Italiano, Laboratorio Sperimentale di Ricerche Auxo-endocrinologiche, IRCCS, Milan, Italy.

Abstract

Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This study evaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m(2)). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p < 0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p < 0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p < 0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p < 0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p < 0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R(2) = 0.64, p < 0.001, and R(2) = 0.52, p < 0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects. Copyright © 2012 S. Karger GmbH, Freiburg.

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